Diplomarbeit / Masterarbeit

Ausschreibung: Aufreinigung des Baculovirus AcMNPV mittels Diafiltration pdf

IMPORTANT NOTES

The APT exam is on Wednesday, 5th October, 9:50 AM - 11:20 AM, in room C801.

Download homework assignment 'Linear Systems'

Bioprocess Systems Engineering

I. Material Balances

Key words: law of conversation of mass; system and process; batch, semi-batch and continuous process, steady-state and equilibrium; integral and differential balance; flow sheet; tie component; recycle, by-pass and purge streams

Literature: P. M. Doran, Bioprocess Engineering Principles, Academic Press, The Netherlands, 2006

sample Material Balances.pdf  sample Material-Bilanzen.pdf

II. Energy Balances

Key words: general energy-balance equation; forms of energy: kinetic, potential, internal; enthalpy calculation procedures: sensible heat, latent heat, heat of solution, heat of reaction; Hess's law; state function and path function; steam tables

Literature: P. M. Doran, Bioprocess Engineering Principles, Academic Press, The Netherlands, 2006

sample Energy Balances.pdf  sample Energiebilanzen.pdf

Supplementary material:
physical and chemical property data, steam tables: download pdf

III. Linear and Nonlinear Systems

Key words: material balances for large scale process flow sheets, split-fraction concept; Nagiev-Rosen technique; labeling procedure: mixers, reactors, separators; systems of linear equations; matrix representation of linear systems; Gaussian elimination; processes with and without reaction; solution of systems of nonlinear equations; Newton's method;

Literature:

M. Discacciati, Numerical Computing for Chemical Engineers, Lecture material, Semester course 2006, Johannes Kepler University Linz, Austria

L.T. Biegler, Advanced Process System Engineering, Lecture Material, Semester course, Carnegie Mellon University Pittshburgh, USA

G. Fieg, Prozess- und Anlagentechnik I, Vorlesungsskript, Institut für Prozess- und Anlagentechnik, Technische Universität Hamburg, Deutschland

Sood et al., Solution of Material Balances for Flowsheets Modelled with Elementary Modules: The Unconstrained Case, AlChE Journal 25 (2) 1979 209-219

C. T. Maravelias, Process Systems Steady-State Modeling and Design, Lecture Material, Semester Course CBE 255, Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, USA

sample Linear and Nonlinear Systems.pdf  sample Lineare und Nicht-lineare Systeme.pdf

Supplementary material:
Excel solution to problem L1: download xls

IV. Dynamic Systems

Key words: general mole balance; material balance for biochemical reactors: stoichiometry of reactions, reaction kinetics, rate expressions, batch reactor, semi-batch process, CSTR; bifurcation; multiplicity of steady-states; solving dynamic problems; ordinary differencial equations; Cauchy-problem; analytical and numerical solution; IVP; numerical solution of ODEs: forward-Euler, backward-Euler, Runger-Kutta method;

Literature:

J. B. Rawlings, J. G. Ekerdt, Chemical Reactor Analysis and Design Fundamentals, Nob Hill Publishing, Madison, Wisconsin, USA, 2004

J. B. Rawlings, Chemical kinetics in well-mixed reactors, Lecture Material, Semester Course CBE 255, Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, USA

S. Elnashaie, F. Uhlig, Numerical Techniques for Chemical and Biological Engineers Using MATLAB : A Simple Bifurcation Approach, Springer, New York, 2007

SuperPro Designer, User's guide, Intelligen Inc., USA, 2001

Z. Kovacs, M. Discacciati, W. Samhaber, Modeling of batch and semi-batch membrane filtration processes, Journal of Membrane Science 327 (2009) 164-173

J.B.Snape, I.J. Dunn, J. Ingham, J.E. Prenosil, Dynamics of Enviromental Bioprocesses - Modelling and Simulation, VCH Publishers, New York, USA, 1995

sample Dynamic problems.pdf  sample Dynamische Systeme.pdf

Supplementary material:
Exercise to problem D3: download pdf
Most common forms of enzyme kinetics: download pdf

V. Linear Programming

Key words: solving a system of linear inequalities; graphical solution; simplex algorithm of Dantzig;

Literature:

B. Lev and H.J. Weiss, Introduction to Mathematical Programming: Quantitative tools for decision-making, North-Holland, New York, USA, 1982

Modellierung und Optimierung, Vorlesungsskript, Institut für Industrie und Fertigwirtschaft, Johannes Kepler Universität Linz, Österreich, 2006

sample xxxxx  sample Lineare Programmierung.pdf

VI. Optimization techniques

Key words: optimization theory overview; formulation of an optimization problem: objective function, model, constraints; linear, quadratic and nonlinear programming; unconstrained and constrained optimization; global vs. local optima; basin of attraction; maximizing vs. minimizing; least-squares optimization (model fitting); iterative methods: Newton's, secant, bisection; direct-search algorithms; Nelder-Mead simplex direct search; pattern search

Literature:

E.K.P. Chong and S.H. Zak, An Introduction to Optimization, Wiley-Interscience Publication, USA, 2nd Edition, 2001

B. Lev and H.J. Weiss, Introduction to Mathematical Programming: Quantitative tools for decision-making, North-Holland, New York, USA, 1982

sample xxxxx  sample xxxxxx

VII. Process simulation

sample Prozesssimulation (Folien)

I. Piping & pump system design

Literature:

R. Herz, Grundlagen der Rohrleitungs- und Apparatetechnik, Vulkan-Verlag GmbH, 2004

DIN standards online: link

sample Rohrleitungstechnik (Folien)  sample Übungen

sample

Bioprocess Modeling with SuperPro Designer

Introduction

Key words: bioprocess development; flowsheet development and initialization; material balances & equipment sizing; process scheduling; economic evaluation; throughput analysis and debottlenecking; inventory tracking for raw materials, intermediates, products, and wastes; tracking demand for resources;

Literature:

E. Heinzle et al., Development of sustainable bioprocesses: modeling and assessment, John Wiley & Sons Ltd, West Sussex, UK, 2006

http://www.intelligen.com/literature.shtml

SuperPro Designer, User's guide, Intelligen Inc., USA, 2001

sample intro.pdf  schnaps_v75.spf  plasmidDNA_v60.spf

Basic Problems I.

Key words: membrane batch diafiltration; multiple reactions in CSTRs in series; continuous anaerobic digester

sample BasicProblemsI.pdf

Basic Problems II.

Key words: xanthan gum production; dynamic analysis of batch fermentation; treatment of food wastwater

sample BasicProblemsII.pdf

Exams to practice

SuperPro Designer exam no.3 on 02/Sept/2009:

sample 02sept2009_english_no3.pdf  sample 02sept2009_deutsch_no3.pdf

SuperPro Designer exam no.2 on 02/Oct/2009:

sample 02oct2009_english_no2.pdf  sample 02oct2009_deutsch_no2.pdf

Flowsheet samples

Download sample flowsheets (version v7.5):

sample1.spf   sample2.spf

Download sample flowsheets (version v6.0):

sample1.spf   sample2.spf